DJ‐1, PINK1, and their effects on mitochondrial pathways
Identifieur interne : 000762 ( Main/Exploration ); précédent : 000761; suivant : 000763DJ‐1, PINK1, and their effects on mitochondrial pathways
Auteurs : Mark R. Cookson [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2010.
English descriptors
- KwdEn :
- DJ‐1, PINK1, genetics, parkin, parkinsonism.
Abstract
Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ‐1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD. © 2010 Movement Disorder Society
Url:
DOI: 10.1002/mds.22713
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">DJ‐1, PINK1, and their effects on mitochondrial pathways</title><author><name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R." last="Cookson">Mark R. Cookson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:AB427D4E84101BD7B956FEBA09627EF2870C9754</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1002/mds.22713</idno><idno type="url">https://api.istex.fr/document/AB427D4E84101BD7B956FEBA09627EF2870C9754/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002788</idno><idno type="wicri:Area/Main/Curation">002443</idno><idno type="wicri:Area/Main/Exploration">000762</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">DJ‐1, PINK1, and their effects on mitochondrial pathways</title><author><name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R." last="Cookson">Mark R. Cookson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, NIH. Bethesda, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010">2010</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">S1</biblScope><biblScope unit="page" from="S44">S44</biblScope><biblScope unit="page" to="S48">S48</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">AB427D4E84101BD7B956FEBA09627EF2870C9754</idno><idno type="DOI">10.1002/mds.22713</idno><idno type="ArticleID">MDS22713</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DJ‐1</term><term>PINK1</term><term>genetics</term><term>parkin</term><term>parkinsonism</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic forms of parkinsonism are interesting for two particular reasons. First, finding a gene identifies a cause for a disease that would otherwise be unexplained. Second, finding several genes for the same disorder allows us to reconstruct molecular pathways that, in the example of Parkinson's disease, are be associated with the survival of dopamine neurons in the substantia nigra. Two rare causes of parkinsonism, DJ‐1 and PINK1, are associated with mitochondria. This organelle has long been linked with Parkinson's disease, and recent results are starting to show how mutations impact mitochondrial function. In this short review, I will discuss how we can use some of this information to understand why it is that neurons become dysfunctional in PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Cookson, Mark R" sort="Cookson, Mark R" uniqKey="Cookson M" first="Mark R." last="Cookson">Mark R. Cookson</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000762 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000762 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:AB427D4E84101BD7B956FEBA09627EF2870C9754
|texte= DJ‐1, PINK1, and their effects on mitochondrial pathways
}}
| This area was generated with Dilib version V0.6.23. |  |